Aniston plays the wife of a New York man who gets fired from his job. The fallout from that forces the high-powered couple to head south to Atlanta so George, played by the always adorable Paul Rudd, can go to work for his brother.

But that Southern scene quickly turns treacherous and the two hit the road again until they crash a hippie commune where the room, sex and goat milk are free.

There's nothing original about a plotline that forces the main characters' off the beaten path to find their truest selves. But expect twists from director David Wain, whose 2008 Role Models was overwhelmingly approved as "certifiably fresh" at Rotten Tomatoes.

In addition to Aniston, Thereaux and Rudd, the movie features Lauren Ambrose, Ken Marino, Joe Lo Truglio and Alan Alda. Look for it at box offices on Feb. 24.